Everyone's endocannabinoid system works in ways that are unique to themselves. Our best chance at success with cannabis is to understand both the science generalizing cannabis use while also learning how our own body functions specifically. On this episode of Shaping Fire, Miyabe Shields PhD returns for Part Two of Endocannabinoid Mechanics and talks with host Shango Los about how minor cannabinoids function, why we find cannabis relaxing, choosing between the various modes of cannabis use for the relief we are looking for, and dosing thresholds for extraordinary ailments like immune disorders, cancer and others.

Today, Dr. Ethan Russo has published his groundbreaking research into the causes of Cannabis Hyperemesis Syndrome. The research team's survey and genomic investigation of patients has, for the first time, identified the genetic mutations affecting neurotransmitters and the endocannabinoid system. In this episode of Shaping Fire, host Shango Los reviews the entirety of the paper with Dr. Russo, including all five of the genetic mutations, the results of the patient survey and why we can exclude causes such as neem.

Everything we require to grow thriving cannabis plants already exists for free in nature. Sure, there are some things that are way easier to buy, but for most of us, wildcrafting our local plants can provide what we need. On this episode of Shaping Fire, host Shango Los talks with permaculture and natural farming educator Joey Burger about how to unleash the power within out local plants for nutrition and pest deterrence.

The endocannabinoid system can seem like a magical engine sometimes and, as cannabis enthusiasts, it's good to dig in and learn how it actually functions. On this episode of Shaping Fire, host Shango Los talks with cannabinoid scientist Miyabe Shields PhD about the chemical mechanics at the basis of our endocannabinoid system, including how cannabinoid receptors function, how cannabinoids take action, why we develop THC tolerance and how to manage it, and the effectiveness of whole plant versus single molecule cannabis medicine.

Every human body has a different capacity to intake and effectively deploy cannabinoids. Humans are often treated as if they all have the same cannabis capacity, and it is simply untrue. On this episode of Shaping Fire, host Shango Los talks with Dr. Chris Spooner about gauging a patient's preparedness for cannabis medicine, what analytics to deploy to properly assess a potential cannabis patient, and what foods to eat that strengthen your endocannabinoid system.

Microdosing mushrooms has suddenly been embraced by much of the medical establishment and regular folks are finding huge benefits. Psilocybin mushroom are increasingly available and good people are using them to relieve trauma, sometimes without understanding how best to use them. In this episode of Shaping Fire, host Shango Los talks with microdosing coach Adam Bramlage to compare microdosing protocols, understand more clearly the differences between doses and how best to explore self-healing safely.

Your relationship with the land you cultivate is perhaps the most important variable for growing thriving cannabis plants. In this episode of Shaping Fire, host Shango Los chats with Nicholas Mahmood of Green Source Gardens about best practices for putting your gardens to sleep in the fall, some ideas for off-season improvements and some strategies to start your spring with abundant force.

The phrase "tissue culture" can get cannabis folks excited and yet not many have a good idea of what it is or how the cannabis plant can benefit from its opportunities. In this episode of Shaping Fire, host Shango Los welcomes back cannabis geneticist Ryan Lee to discuss what tissue culture is, the opportunities found in micropropagation, how to remove viruses and other impediments from important cannabis cultivars, and the wide range of other scientific possibilities that tissue culture holds.

Autoflowering cannabis cultivars have come a long way in the last decade. On this episode of Shaping Fire, host Shango Los talks with autoflower breeder and co-founder of Autoflower.net Dan Jimmie aka Mandalorian Genetics about the early days of autoflowers, the genetic breakthroughs since 2008, the establishment of a forum dedicated to the autoflower community and the basics of why breeding autoflowers is trickier than photosensitive varieties.

Prohibitionists often argue that cannabis causes psychotic breaks and schizophrenia. And while the science does not support that position, schizophrenia is not entirely unrelated to cannabis use either. In this episode of Shaping Fire, host Shango Los talks with neuroscientist Greg Gerdeman about what exactly schizophrenia is, the science looking at the relationship between psychosis and cannabis, and the systemic prejudice against cannabis in mental health care.